Comparison of effects of two drugs given intravenously on blood pressure ,heart rate and response during removal of endotracheal tube in patients undergoing General Surgery.

Comparative evaluation of effects of intravenous Dexmedetomidine and intravenous Fentanyl on hemodynamic and extubation response during tracheal extubation in elective General Surgery patients. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072696

Enrollment

150

Registered

2024-08-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K402- Bilateral inguinal hernia, withoutobstruction or gangrene Health Condition 2: K800- Calculus of gallbladder with acutecholecystitis Health Condition 3: K801- Calculus of gallbladder with othercholecystitis Health Condition 4: K802- Calculus of gallbladder without cholecystitis Health Condition 5: C503- Malignant neoplasm of lower-innerquadrant of breast Health Condition 6: C505- Malignant neoplasm of lower-outerquadrant of breast Health Condition 7: C502- Malignant neop

Interventions

Intervention1: Injection Dexmedetomidine 0.5mcg/kg: Injection Dexmedetomidine 0.5mcg/kg diluted in 20 ml Normal saline will be given intravenously through infusion pump over 5 minutes to one group of

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex between 18-60 years of age Patients weighing between 50-70 kgs Patients belonging to ASA grade 1 and 2 Patients undergoing elective surgeries under General Anaesthesia Written informed consent Duration of surgery-45 to 120 minutes

Exclusion criteria

Exclusion criteria: Patients unwilling to given consent for proposed study Patients in whom General Anaesthesia will be contraindicated Patients with Cardiovascular disorder,Respiratory disorder,Diabetes,Hypertension and obesity. Patients allergic to Dexmedetomidine and Fentanyl Patient fitting in the criteria of difficult intubation (Mallampatti grade 3 and 4) Patients with anticipated difficult airway

Design outcomes

Primary

Measure	Time frame
Hemodynamic responses such as Heart rate,Systolic blood pressure,Diastolic blood pressure,Mean arterial pressure and SaturationTimepoint: Mean arterial pressure 62% better than comparator agent	—

Secondary

Measure	Time frame
Time to extubation and extubation response Post operative sedation Visual analogue score and need for analgesic requirement Adverse effectsTimepoint: Extubation quality is 4 times better than comparator agent	—

Countries

India

Contacts

Public ContactDr Dheeraj Prakash Gupta

Hindu Rao Hospital

drdheerajpgupta@gmail.com9873151754

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026