Comparing the effect of ultrasound guided Erector spinae plane block and Serratus anterior plane block on the immune system response in patients undergoing breast cancer surgery

Effect of ultrasound guided Erector spinae plane block and Serratus anterior plane block on inflammatory response in patients undergoing Modified radical mastectomy under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072663

Enrollment

Registered

2024-08-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: Erector Spinae Plane Block: After induction of general anaesthesia, ultrasound guided Erector spinae plane block at T4-T6 vertebral level will be administered with 20ml 0.5% Ropivacain

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1, 2, 3 patients

Exclusion criteria

Exclusion criteria: 1. Bleeding diathesis 2. Local skin infection at the site of block 3. Allergy to local anaesthetics or adjuvants

Design outcomes

Primary

Measure	Time frame
1. Serum IL-6 concentration in both the groups 2. Serum IL-10 concentration in both the groupsTimepoint: Baseline and 24 hours post-operatively	—

Secondary

Measure	Time frame
Serum cortisol concentrations in both the groupsTimepoint: Baseline and 24hrs postoperatively;Time at which the first rescue analgesia is requested by the patient postoperatively as assessed by the NRS pain score in both the groupsTimepoint: 2hrs, 6hrs, 12 hrs and 24hrs postoperatively;Total amount of opioid consumption within 24 hours postoperatively in both the groupsTimepoint: 24 hrs postoperatively;Total consumption of intravenous Fentanyl in both the groupsTimepoint: During the duration of the surgery	—

Measure

Time frame

Serum cortisol concentrations in both the groupsTimepoint: Baseline and 24hrs postoperatively;Time at which the first rescue analgesia is requested by the patient postoperatively as assessed by the NRS pain score in both the groupsTimepoint: 2hrs, 6hrs, 12 hrs and 24hrs postoperatively;Total amount of opioid consumption within 24 hours postoperatively in both the groupsTimepoint: 24 hrs postoperatively;Total consumption of intravenous Fentanyl in both the groupsTimepoint: During the duration of the surgery

—

Countries

India

Contacts

Public ContactDr Neelam Prasad

Maulana Azad Medical College

nprasadgovil@yahoo.com01123238058

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026