Comparing Pain Relief of Nalbuphine and Butorphanol with Ropivacaine in Abdominal and Leg surgeries

Comparison of the analgesic efficacy of nalbuphine versus butorphanol as an adjuvant to 0.75 percentage hyperbaric ropivacaine in lower abdominal and lower limb surgeries - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072624

Enrollment

Registered

2024-08-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: GROUP N(0.75% hyperbaric ropivacaine and nalbuphine): 0.75% hyperbaric ropivacaine 2.2 ml (16.5 mg)+0.8 ml (0.8mg) of nalbuphine (N) intrathecally once. Post operative analgesic efficac

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA physical status 1 and 2 2. BMI range of 18.5 to 24.9

Exclusion criteria

Exclusion criteria: 1.Infection at the site 2.Spinal deformity such as kyphoscoliosis 3.Bleeding disorders 4.Allergic reaction to study drugs 5.Patients on tranquilizers,hypnotics,sedatives and other psychotropic drugs

Design outcomes

Primary

Measure	Time frame
Postoperative analgesic durationTimepoint: Pain assessment 2 hourlies until 12 hours	—

Secondary

Measure	Time frame
Duration of motor blockadeTimepoint: Assessed 2 hourlies until 12 hours of post surgery;Duration of sensory blockadeTimepoint: Assessed 2 hourlies until 12 hours of post surgery;The onset of sensory and motor blockade Timepoint: Assessed immediately after spinal injection then, every 3 minutes until 15 minutes, then every 10 minutes upto 1 hour, then every 30 minutes upto 2 hours and then hourly till the end of the surgery	—

Measure

Time frame

Duration of motor blockadeTimepoint: Assessed 2 hourlies until 12 hours of post surgery;Duration of sensory blockadeTimepoint: Assessed 2 hourlies until 12 hours of post surgery;The onset of sensory and motor blockade Timepoint: Assessed immediately after spinal injection then, every 3 minutes until 15 minutes, then every 10 minutes upto 1 hour, then every 30 minutes upto 2 hours and then hourly till the end of the surgery

—

Countries

India

Contacts

Public ContactDR Jyothi B

Karnataka Institute of Medical Sciences

drjyothib1@gmail.com9886187056

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026