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Chair-side diagnostic kit for estimation of growth factor in saliva for prediction of bone maturity status in orthodontic patients

Development and validation of Lateral flow immunoassay (LFIA) based point of Care (POC) diagnostic kit for salivary IGF-1 to predict skeletal maturity - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/08/072606
Enrollment
282
Registered
2024-08-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K14- Diseases of oral cavity and salivary glands Health Condition 2: K08- Other disorders of teeth and supporting structures

Interventions

Intervention1: NIL: NIL

Sponsors

Dental Technology Innovation Hub
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients visiting the OPD of Department of Orthodontics with no previous history of orthodontic/orthopedic treatment

Exclusion criteria

Exclusion criteria: 1. Subjects with bone-related metabolic disorders or skeletal defects 2. Subjects who are under any medications or growth hormone therapy 3. History of xerostomia 4. History of trauma or surgery in area of cervical vertebrae

Design outcomes

Primary

MeasureTime frame
Development of a novel, indigenously prepared, low cost, rapid, chair side POC diagnostic kit for salivary IGF-1 in estimating the pubertal growth status. The lateral flow based IGF-1 based portable kits will revolutionize the orthodontic sciences in accurately predicting the pubertal growth spurt instantly for successful growth modification procedures. Potential impact: 1.A commercially available chair side diagnostic kit, reducing the treatment planning time 2.Implementing timely intervention through utilization of full growth potential and alleviate the burden of surgical intervention. 3.To identify children with growth hormone discrepancies / delayed growth Timepoint: 1st and 2nd year-Subject enrolment, salivary sample collection 2nd year- Analysis of data and development and testing of POC kit 3rd year- Validation of POC kit—

Secondary

MeasureTime frame
The diagnostic kit holds the potential for translational research applications in the future, particularly in identifying and screening children experiencing growth hormone discrepancies or delayed growth.Timepoint: 1st and 2nd year-Subject enrolment, salivary sample collection 2nd year- Analysis of data and development and testing of POC kit 3rd year- Validation of POC kit—

Countries

India

Contacts

Public ContactTulika Tripathi

Maulana Azad Institute of Dental Sciences

drtulikatripathi@yahoo.com9654700970

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026