Chitosans Role in Enhancing Bone Regeneration and Healing in Dental Extraction Sites: A Split Mouth Study

Evaluation of Chitosan in Promoting Bone Regeneration and Healing of Extraction Socket -A Split Mouth Study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072526

Enrollment

Registered

2024-08-14

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z768- Persons encountering health services in other specified circumstances

Interventions

Intervention1: Chitosan: 100% commercially available chitosan placement in post extraction socket of asymptomatic mandibular third molar for 24 hours Control Intervention1: Placebo group: no medicame

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I and II 2. Subjects with bilateral tooth extraction

Exclusion criteria

Exclusion criteria: 1. Systemically compromised patients 2. Hypersensitivity to crustacean group 3. Sea Food and protein allergy 4. Active Infection 5. Chronic substance abuse. 6. Subjects with poor oral hygiene 7. Subjects who are not willing for the study 8. Specially challenged individuals

Design outcomes

Primary

Measure	Time frame
Difference in wound healing between test sites versus control site and categorized as percentage of sites that are worse than right side, same as right side, better than right side Percentage of sites with infection between test site versus control- Pus present or absent Mean pain score between test and control groups Difference in Radiographic findings of test sites versus control sites and categorized as percentage worse than right side, same as right side, better than right side Timepoint: Wound healing and infection is observed on the 3rd and 7th days following tooth extraction Pain scores are recorded after 24hr 72hr 5th day and 7th day following tooth extraction using visual analog scale using a 0 to 10 pain score basis with 0 being no pain and 10 being the worst pain experienced Radiographic findings will be evaluated by observing lamina dura and density of the extraction socket by using the scale mentioned at 4 weeks 8 weeks and 12 weeks following tooth extraction	—

Measure

Time frame

Difference in wound healing between test sites versus control site and categorized as percentage of sites that are worse than right side, same as right side, better than right side Percentage of sites with infection between test site versus control- Pus present or absent Mean pain score between test and control groups Difference in Radiographic findings of test sites versus control sites and categorized as percentage worse than right side, same as right side, better than right side Timepoint: Wound healing and infection is observed on the 3rd and 7th days following tooth extraction Pain scores are recorded after 24hr 72hr 5th day and 7th day following tooth extraction using visual analog scale using a 0 to 10 pain score basis with 0 being no pain and 10 being the worst pain experienced Radiographic findings will be evaluated by observing lamina dura and density of the extraction socket by using the scale mentioned at 4 weeks 8 weeks and 12 weeks following tooth extraction

—

Secondary

Measure	Time frame
Effectiveness of Chitosan in accelerating bone formationTimepoint: The bone formation will be assessed after the first month second month & third month following tooth extraction	—

Countries

India

Contacts

Public ContactDr Manoj Kumar KP

KMCT Dental College

mnjkmrkp@gmail.com9847005213

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026