Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adults(age = 18 years) 2.Mechanically ventilated for = 48 hours due to medical or surgical reasons 3.Eligible for a SBT as decided by the intensivist, according to ACCP/ATS/ERS guidelines
Exclusion criteria
Exclusion criteria: 1.Neuromuscular disorders affecting respiratory muscles 2.Contraindications for ultrasound examination (e.g., chest wounds, subcutaneous emphysema) 3.Refusal to participate in the study 4.Pregnancy 5.Morbid obesity 6.Neuromuscular blocking agents within 48 hours preceding diaphragm function assessment 7.Pneumothorax, pneumomediastinum, flail chest, or rib fractures 8.Patients primarily ventilated due to cardiac failure 9.Patients with diaphragmatic paralysis/injury on admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the area under the receiver operating characteristic curves(AUROCs) of airway occlusion pressure (P0.1), parasternal intercostal muscle thickening fraction/Diaphragm thickening fraction ratio (PMTF/DTF), and Diaphragm thickening fraction/Rapid shallow breathing index ratio (DTF/RSBI) to predict weaning outcome in critically ill mechanically ventilated patients.Timepoint: 48 hours after Mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To compare P0.1, PMTF/DTF ratio, and DTF/RSBI ratios on subsequent spontaneous breathing trials (SBTs) 2.To correlate PMTF and DTF on the day of discharge from the intensive care unit (ICU) with the number of days of mechanical ventilation and length of stay (LOS) in the ICU. Timepoint: 48 hours after Mechanical ventilation till discharge from ICU | — |
Countries
India
Contacts
Public ContactLahareesh B L
AIIMS, New Delhi
Outcome results
None listed