Health Condition 1: S00-T88- Injury, poisoning and certain other consequences of external causes
Conditions
Interventions
Intervention1: Erythromycin: 500 mg erythromycin dissolved in 10 ml water given 1 hour before feed via NG/OG tube
Control Intervention1: Placebo: 10 ml of water given via NG/OG tube 1 hour before bolu
Sponsors
AIIMSNew Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1 Severe TBI (GCS:3-8) 2. Exclusively enteral fed by NG/OG tube 3. On bolus enteral feeding with established feeding pattern 4.Receiving formula feed
Exclusion criteria
Exclusion criteria: 1. Refusal for consent by the patient attenders 2. Severe TBI associated with spinal cord injuries 3. Severe TBI associated with bowel injuries 4. Severe TBI with thoracic injuries 5. Patients on parenteral nutrition. 6. Patients with feeding intolerance 7. Pregnant & lactating mothers 8. Patient with associated renal & hepatic dysfunction 9. Known hypersensitivity reaction with erythromycin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of erythromycin versus placebo on gastric residual volume, measured hourly for 6 hours with Ultrasound after bolus feeding in severe TBI patientsTimepoint: hourly for 6 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse drug effects associated with erythromycin: rash, diarrhoea, cardiac arrhythmia Timepoint: 24 hours;Incidence of feeding intolerance Timepoint: defined as gastric residual volume of more than 300 ml at the end of 6 hour;To study factors associated with delayed gastric emptying – -Raised ICP -Glycemic control -Electrolyte imbalances -Use of Sedative agents -Use of vasopressor/ ionotropic agents Timepoint: 6 hours;To study the effect of erythromycin on peristaltic movement Timepoint: 6 hours | — |
Countries
India
Contacts
Public ContactChitra Prabha Saun
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed