Using noradrenaline infusion in low dose to prevent postoperative memory disturbances in elderly surgical patients

Efficacy of prophylactic low dose Noradrenaline infusion upon postoperative cognitive dysfunction in elderly surgical patients - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072436

Enrollment

Registered

2024-08-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: GROUP A: Intraoperatively prophylactic low dose that is 0.02 µg/kg/min of noradrenaline infusion given intravenously along the duration of surgery Control Intervention1: GROUP B: Contr

Eligibility

Inclusion criteria

Inclusion criteria: Age 60–85 years Elderly patients scheduled for surgeries American Society of Anesthesiologists (ASA) grade was I-IV grades

Exclusion criteria

Exclusion criteria: Bradycardia heart rate less than 50 bpm Atrioventricular block higher than first degree Abnormal liver or renal function Patients who presented mini mental state examination score of less than 23 Patients with pre existing cognitive dysfunction or severe auditory or visual disability Patients with prior cardiac or neurosurgical procedures

Design outcomes

Primary

Measure	Time frame
To evaluate the change in incidence of post operative cognitive dysfunction in elderly surgical patientsTimepoint: Day 1	—

Secondary

Measure	Time frame
To monitor post operative hemodynamic changesTimepoint: Day 1	—

Countries

India

Contacts

Public ContactDr Anupama R Nair

Vinayaka Missions Medical College

ramadas.anupama@gmail.com9447348345

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026