Health Condition 1: L400- Psoriasis vulgaris
Conditions
Interventions
Intervention1: Effectiveness and safety of Oral Methotrexate and Oral tofacitinib in the Treatment of Chronic Plaque Psoriasis .
: GROUP A – Oral MTX 7.5mg weekly once and T.FOLIC ACID 5mg od to be gi
Sponsors
Rishana N
Eligibility
Inclusion criteria
Inclusion criteria: Chronic plaque psoriasis with PASI more than 10. Patient with nail psoriasis. Patient with Psoriatic arthritis.
Exclusion criteria
Exclusion criteria: Pregnancy and lactation. Females and males who were planning to have a child and not willing for using contraception. Systemic therapy taken for psoriasis in the past 4 weeks before enrolling into the study. Topical therapy taken for psoriasis in past 2 weeks before enrolling into the study. Acute or chronic liver disease or renal disease/ uncontrolled hypertension/ uncontrolled Diabetes mellitus. known allergy to any of the study drugs. Active infection such as Tuberculosis, HIV, Hepatitis B and C. History of disseminated herpes zoster or herpes simplex or recurrent localized dermatomal herpes zoster. Patient on any other immunosuppressants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PASI50 PASI75 PASI90 NAPSI ACR20 ACR50 ACR70Timepoint: 0,4TH,8TH,12TH,16TH,20TH WEEK | — |
Secondary
| Measure | Time frame |
|---|---|
| PATIENT SATISFACTION SCORE PHYSICIAN GLOBAL ASSESSMENT SCORETimepoint: 20TH WEEK | — |
Countries
India
Contacts
Public ContactRishana N
SRM Medical College Hospital And Research Centre
Outcome results
None listed