to study the role of Hypochlorous acid eye drops in faster healing of cases of corneal fungal infections.

Comparative Evaluation of Topical 0.01% Hypochlorous Acid vs standard therapy In Fungal Keratitis: A Prospective Randomized Controlled Clinical Trial - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072389

Enrollment

104

Registered

2024-08-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: 0.01% hypochlorous acid (HOCL) eye drops (in saline): 0.01% HOCL eye drops (prepared in normal saline) will be administered hourly for first hourly for two days along with routine treat

Eligibility

Inclusion criteria

Inclusion criteria: 1. Eligible patients with smear-positive fungal corneal ulcer 2. Baseline visual acuity of 20/40. 3. Patients age should be more than 16 4. Willing to participate

Exclusion criteria

Exclusion criteria: 1. Impending perforation 2. Evidence of bacterial, Acanthamoeba, or herpetic keratitis; 3. Age less than 16 years 4. Bilateral ulcers or visual acuity worse than 20/200 (1.0 logMAR) in the nonaffected eye 5. Pregnancy, by history or urine test, or breastfeeding. 6. Known allergy to study medication.

Design outcomes

Secondary

Measure	Time frame
Improvement in Visual AcuityTimepoint: Day 0,Day 2, Day7, Day14,Day 21, Day60, Day90, Day120, Day150, Day180	—

Primary

Measure	Time frame
1. Time to epithelization and time to healing. 2. Scar size post healing Timepoint: Day 0,Day 2, Day7, Day14,Day 21, Day60, Day90, Day120, Day150, Day180	—

Countries

India

Contacts

Public ContactDr Namrata Sharma

AIIMS, New Delhi

namrata.sharma@gmail.com9868398412

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026