Preoxygenation during endotracheal intubation to prevent drop in saturation during intubation.

High flow oxygenation as a mode of Preoxygenation during Endotracheal intubation in children An open label randomised control study HOPE TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072376

Enrollment

118

Registered

2024-08-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: J22- Unspecified acute lower respiratory infection Health Condition 3: J22- Unspecified acute lower respiratory infection

Interventions

Intervention1: HFNC: HFNC is a mode of oxygenation for 3 minutes duration prior to introduction of laryngoscope Control Intervention1: Non rebreathing mask: NRBM is a mode of oxygenation for 3 minutes

Eligibility

Inclusion criteria

Inclusion criteria: All children between 1month to 18 years requiring endotracheal intubation

Exclusion criteria

Exclusion criteria: Children in cardiac arrest Anatomical difficult airway Children under NIV Did not consent for participation

Design outcomes

Primary

Measure	Time frame
1.To compare the effect of HFNC vs NRBM as a method of preoxygenation on desaturation during endotracheal intubation in children. 2.Time in seconds for desaturation during endotracheal intubation Timepoint: Baseline	—

Secondary

Measure	Time frame
To compare the following parameters between two groups 1.Median lowest oxygen saturation 2.Median time for lowest oxygen saturation 3.Median highest ETco2 after intubation 4.Number of patients with SPo2 less than 80% 5.Hemodynamic adverse events peri intubation 6.Duration of mechanical ventilation 7.Duration of PICU stay Timepoint: Baseline	—

Countries

India

Contacts

Public ContactGowthami Priya Lagudu

St Johns medical College

drlalitha03@gmail.com09448461673

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026