Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: nil: nil
Control Intervention1: Fertile Controls
: Healthy oocyte donors willing to participate in study will undergo one time sampling
Control Intervention2: Unexplained Infertility
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Group1 Inclusion (Fertile controls) i. Healthy oocyte donors aged 20-35 years ii. Willing to participate in the study Group 2 (Unexplained Infertility) Women age 20-35 years and willing to participate in the study Group 3 ( Recurrent implantation failure ) i. Women undergoing 2 failed fresh or frozen transfer of good quality embryos ii. Women aged 20-36 years iii. Willing to participate in the study
Exclusion criteria
Exclusion criteria: Group 1 (Fertile controls) i. On any hormone therapy including oral contraceptive ii. On recent use of antibiotics or probiotic therapy iii. With immune disorders including SLE, Rheumatoid arthritis Group 2 ( Unexplained infertility) i. On any hormone therapy including oral contraceptive ii. On recent use of antibiotics or probiotic therapy iii. Severe male factor infertility iv. Endometriosis in female v. Tubal factor and or presence of hydrosalpinges on HSG/ USG vi. Endometrial TB vii. Sub-mucous fibroids or polyp Group 3 ( Recurrent implantation failure) i. On any hormone therapy including oral contraceptive ii. On recent use of antibiotics or probiotic therapy iii. Women with endometriosis, tubal factor infertility iv. Endometrial TB v. Sub-mucous fibroids or polyp vi. Uterine adenomyosis vii. Unwilling to participate in study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •To characterize the microbiota from endometrial fluid samples in fertile Indian women during the widow of implantation •To compare the endometrial microbiota in women with RIF and unexplained infertility with microbiota from fertile age matched women during the window of implantation. Timepoint: Baseline sample only | — |
Secondary
| Measure | Time frame |
|---|---|
| To characterize the microbiota from endometrial fluid samples in fertile Indian women during the widow of implantation • To compare the endometrial microbiota in women with RIF and unexplained infertility with microbiota from fertile age matched women during the window of implantation. Timepoint: 0-12 months Recruitment of subjects 3-10 months Collection of endometrial samples and transport for metagenomic analysis 9-12 months Analysis and interpretation of results | — |
Countries
India
Contacts
Public ContactNeena Malhotra
All India Institute of Medical Sciences
Outcome results
None listed