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A clinical trial to comparatively evaluate dexmedetomidine versus butorphanol for attenuation of etomidate-induced myoclonus

Comparative evaluation of dexmedetomidine and butorphanol for attenuation of etomidate-induced myoclonus - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/08/072310
Enrollment
80
Registered
2024-08-12
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D179- Benign lipomatous neoplasm, unspecified Health Condition 2: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: NIL: NIL Intervention2: Comparative evaluation of dexmedetomidine and butorphanol for attenuation of etomidate-induced myoclonus: Patients will be randomly allocated into two groups eac

Sponsors

Dayanand Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patient of either sex between 18 years to 60 years for surgery under general anesthesia belonging to American society of Anaesthesiologist(ASA) Class 1 or 2 with BMI less than 30 and scheduled for elective surgery under general anesthesia will be included in study for comparative evaluation of dexmedetomidine and butorphanol for attenuation of etomidate-induced myoclonus.

Exclusion criteria

Exclusion criteria: 1. Patients with bradycardia (heart rate less than 60 per minute , having arrythmias or AV block, on beta blockers or having pacemaker in situ 2. Known case of hypoadrenalism 3. Pregnant or lactating patients 4. Known hypersensitivity to etomidate 5. Patient refusal

Design outcomes

Primary

MeasureTime frame
The primary outcome will be measured as the incidence of etomidate-induced myoclonusTimepoint: The participants will be observed for 1 minute after induction of anaesthesia

Secondary

MeasureTime frame
The secondary outcome will be measured as observed side-effectsTimepoint: 1 minute interval for initial 10 minutes and then every 5 minutes for 60 minutes;The secondary outcome will be measured as the severity of etomidate-induced myoclonus using 4 point grading scaleTimepoint: 1 minute after induction of anesthesia

Countries

India

Contacts

Public ContactNavdeep Singh

Dayanand Medical College and Hospital

navdeep00099@gmail.com7986772790

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026