Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Infusion dose of Dexmedetomidine with a bolus dose of 1 mcg/kg intravenously followed by a maintenance dose of 0.2mcg/kg/hour: After induction of anesthesia and endotracheal intubation,
Sponsors
Rajendra Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: a. Patients belonging to ASA grade I and II. b. Patients give informed and written consent for surgery. c. Patients aged 60 years or more. d.Patients undergoing elective abdominal surgeries lasting for 2 or more hours but not more than 4 hours under General Anesthesia.
Exclusion criteria
Exclusion criteria: Patients belonging to ASA grade III & IV, Patients who refuse consent, Patients with pre existing diagnosis of Schizophrenia or Dementia or any condition which affects cognition, Patients with visual and hearing impairment, Patients with communication barriers who could not complete the cognition test and patients with pre operative Montreal Cognitive Assessment score less than 26.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether the use of intraoperative Dexmedetomidine is associated with a decreased incidence of post-operative cognitive dysfunction in elderly patientsTimepoint: MOCA scale will be used to assess patients cognition status before surgery and 1 hour after surgery 6 hours after surgery 24 hours after surgery and preoperative and postoperative cognition scores will be compared | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine at which dose Dexmedetomidine has a more favourable effect on postoperative cognitive dysfunction and whether Dexmedetomidine plays a role in post operative analgesia.Timepoint: For 1 hour,6 hours, and 24 hours after end of general anesthesia. | — |
Countries
India
Contacts
Public ContactDr Mukesh Kumar
Rajendra Institute of Medical Sciences
Outcome results
None listed