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effect of giving magnesium sulphate before surgery on decreasing muscle contractions caused by succinylcholine, muscle pain after surgery and effect on serum pottasium

Effect of pretreatment with MgSO4 in decreasing succinyl choline induced fasciculations, post operative myalgia and its effect on serum pottasium - nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/08/072257
Enrollment
96
Registered
2024-08-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R253- Fasciculation

Interventions

Intervention1: magnesium sulphate IV: Preoperative injection of magnesium sulphate 40mg/kg diluted in 0.9% NS to a total volume of 10 mL Control Intervention1: nil: nil

Sponsors

Rajendra institute of medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: written and informed consent, patients aged between 20 and 50 years posted for elective surgery under general anesthesia. ASA (American society of anesthesiologists) grade I and grade II pre-operative serum magnesium within normal limits

Exclusion criteria

Exclusion criteria: Consent refusal ASA grade III and IV Abnormal levels of serum magnesium and serum calcium History of adverse drug reactions to relevant drugs ASA grade III or above contraindication to administration of relevant drugs BMI more than 25 or less than 18

Design outcomes

Primary

MeasureTime frame
grade of fasciculations after administration of succinyl choline grade of post operative myalgia serum potassium levels following intubationTimepoint: post operative myalgia will be measured 24 hours after surgery serum potassium levels will be measured immediately after intubation

Secondary

MeasureTime frame
hemodynamic response to intubationTimepoint: measured at one, three, five and ten minutes

Countries

India

Contacts

Public ContactBharati

Rajendra institute of medical sciences

dr.ladhulakra007@gmail.com9835160608

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026