Health Condition 1: I609- Nontraumatic subarachnoid hemorrhage, unspecified
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
National Institute of Mental Health and Neurosciences (NIMHANS)
Indian Society of Neuroanesthesiology and Critical Care
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18-65 years with poor grade SAH (World Federation of Neurologic Surgeons [WFNS] grade III-V) Patients requiring treatment with intra-arterial nimodipine under anaesthesia for a minimum of 3 sessions
Exclusion criteria
Exclusion criteria: Pregnancy Patients with established territorial infarct.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Procaspase-3:cleaved caspase-3 ratio, following repeated exposures among different anaesthetic agentsTimepoint: Before the first and after the last intraarterial nimodpine injection (at baseline and at 5th day) | — |
Secondary
| Measure | Time frame |
|---|---|
| [1] Compare the difference in Procaspase-3:cleaved caspase-3 ratio before and after exposure to the individual anaesthetic agents (pre-exposure vs post -exposure difference) [2] Compare the CT-scan based cerebral infarct volumes following repeated anaesthetic exposures [3] Compare the clinical outcome of patients at discharge (GOSE) following exposure to different anaesthetic agents Timepoint: 1.Before the first and after the last intraarterial nimodipine injection 2. CT scan before and after intrarterial nimodipine injections 3. at discharge | — |
Countries
India
Contacts
Public ContactDr Sonia Bansal
NIMHANS
Outcome results
None listed