Health Condition 1: K055- Other periodontal diseases
Conditions
Interventions
Intervention1: Probitics (velbiom): 200 CFU
Twice Daily Orally for 15 Days
Control Intervention1: Antibiotics: Tablet Amoxicillin 500 mg and Tablet Metronidazole 400 mg
combination) given orally for
Sponsors
Dr Mohini Gautam
Eligibility
Inclusion criteria
Inclusion criteria: a) Both male and female participants aged between 18 to 75 years with and without a history of diabetes will be included; b) Participants diagnosed with swelling in periodontium which is diagnosed as a periodontal abscess with a pre- existing periodontal pocket) as defined by the 2017 classification; c) Participants having more than 3 mm probing depth and interdental bone loss as diagnosed with the radiograph or clinical attachment loss of more than 1 mm with bleeding on probing present. d) Patients with a minimum of 10 functional teeth.
Exclusion criteria
Exclusion criteria: a) Participants with a history of any systemic disease/conditions other than diabetes; b) Participants with a history of any drug intake/medication for any systemic disease other than diabetes mellitus; c) Participants reporting any allergy to amoxicillin and metronidazole d) Current and former smokers and those consuming alcohol; e) Participants with any form of oral abusive habit such as gutka, pan, supari, areca nut,etc.; f) Participants undergoing any radiation or chemotherapy; g) Pregnant and lactating women ; h) Participants who have undergone any periodontal therapy in the previous month ; i) Participants who were under any antibiotics in the previous three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in microbial profile, colony forming unit, and CRP levels before and after the interventionTimepoint: At Baseline and 15 days | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate and compare the changes in the microbial profile in subgingival biofilm and serum of patients with periodontal abscesses before and after the probiotics and antibiotics treatment. To evaluate the change in the C-reactive proteins (CRP) in the serum of patients with periodontal abscess before and after taking probiotics compared to antibioticsTimepoint: Baseline , 7 day , 15 day | — |
Countries
India
Contacts
Public ContactDr Mohini Gautam
Manipal College of Dental Science, Manipal, Manipal Academy of Higher Education
Outcome results
None listed