Health Condition 1: G09- Sequelae of inflammatory diseasesof central nervous system
Conditions
Interventions
Intervention1: levetiracetam: 1st loading dose 30mg/kg IV over 20 mins , 2nd loading dose 30mg/kg IV over 20 mins
Control Intervention1: phenobarbitone: 1st loading dose 20mg/kg IV Slowly over 20 mins
Sponsors
RNT MEDICAL COLLEGE
Eligibility
Inclusion criteria
Inclusion criteria: 1)EEG confirmed seizure in all Term and Pre-term babies admitted in NICU 2)Those patients whose guardian has given informed consent.
Exclusion criteria
Exclusion criteria: 1) Neonates with electrolyte imbalance ( Hyponatremia and Hypernatremia) 2)Hypoglycemia 3)Hypocalcemia 4) Hypomagnesemia 5)Any previous history of receiving ASM • Family history of any seizure disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patients achieving seizure control after first and second loading dose of the drug i.e., Phenobarbitone or Levetiracetam and remaining seizure free for next 24 hours will be considered as primary outcomeTimepoint: 24hr | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients having adverse effects occurring within 2 hours of drug administration will be considered as secondary outcome.Timepoint: 2hr | — |
Countries
India
Contacts
Public ContactDr Bhupesh Jain
RNT MEDICAL COLLEGE
Outcome results
None listed