Health Condition 1: N912- Amenorrhea, unspecified
Conditions
Interventions
Sponsors
Research Section Thesis Grant AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Subjects Women with POI meeting all the following criteria - Age less than 40 years - Secondary amenorrhea for at least four months - Elevated FSH 25.0 IU/L on two occasions at least 4 weeks apart Controls - Age and parity matched healthy women with normal menstrual cycles and serum FSH in normal range
Exclusion criteria
Exclusion criteria: Both subjects and controls - History of surgery on tubes/ovaries, post radiation, post chemotherapy - Any systemic illness, History of chronic renal disease - Hyperthyroidism, hyperparathyroidism - On corticosteroids and anticonvulsant therapy which are known to affect bone metabolism - Unwilling to give written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMD at the spine and hip, TBS, serum levels of Osteopontin, P1NP, Beta Cross LapsTimepoint: At baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| - Number of women with POI who have bone density scores less than one standard deviation below the mean of the reference group in spine and/or hip region - Correlation of biomarkers levels with BMD & TBS - Questionnaire to assess awareness of POI & its impact on bone.Timepoint: At baseline | — |
Countries
India
Contacts
Public ContactDr Pragya Shukla
AIIMS New Delhi
Outcome results
None listed