A study comparing tiny particles of hydroxyapatite alone and with herbal gel for treating bony defects using clinical and radiographic methods.

Comparative evaluation of hydroxyapatite nanoparticles with and without herbal gel in the treatment of periodontal intrabony osseous defects: A Clinico-Radiographic Study - Nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072016

Enrollment

Registered

2024-08-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Novel composite graft: Combination of hydroxyapatite nanoparticles and herbal gel containing bromelain and banana peel. Intervention2: Novel Composite graft: Pectin, bromelain, hydroxya

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients with stage III periodontitis assessed by probing pocket depth (PPD) â?¥ 6mm, interdental clinical attachment loss (CAL) â?¥ 5mm. 2) Patients with two or three wall intraosseous defects in either maxillary or mandibular arch or interarch.

Exclusion criteria

Exclusion criteria: 1) Patients with history of systemic diseases, allergy or drug usage. 2) Patients who have undergone periodontal treatment in previous 6 months. 3) Pregnant or lactating women. 4) Smokers, tobacco chewers and patients with poor oral hygiene index will be excluded from the study. 5) In addition, tooth with caries, mobility greater than grade II will be excluded.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the efficacy of hydroxyapatite nanoparticles with and without herbal gel in the treatment of periodontal intrabony osseous defects, clinically and radiographically by CBCT.Timepoint: Baseline, 3 months and 6 months.	—

Secondary

Measure	Time frame
1) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intraosseous bony defects when treated with herbal gel with hydroxyapatite nanoparticles at baseline, 3 months and 6 months post operatively. 2) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intraosseous bony defects when treated with hydroxyapatite nanoparticles at baseline, 3 months and 6 months postoperatively. 3) To assess radiographic bone fill obtained in intraosseous bony defects when treated herbal gel with hydroxyapatite nanoparticles at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). 4) To assess radiographic bone fill obtained in intraosseous bony defects when treated with hydroxyapatite nanoparticles at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). Timepoint: Baseline, 3 months and 6 months.	—

Measure

Time frame

1) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intraosseous bony defects when treated with herbal gel with hydroxyapatite nanoparticles at baseline, 3 months and 6 months post operatively. 2) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intraosseous bony defects when treated with hydroxyapatite nanoparticles at baseline, 3 months and 6 months postoperatively. 3) To assess radiographic bone fill obtained in intraosseous bony defects when treated herbal gel with hydroxyapatite nanoparticles at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). 4) To assess radiographic bone fill obtained in intraosseous bony defects when treated with hydroxyapatite nanoparticles at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). Timepoint: Baseline, 3 months and 6 months.

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Countries

India

Contacts

Public ContactDr. Surekha Rathod

Ranjeet Deshmukh Dental College and Research Centre, Nagpur.

drsurekhar@gmail.com9011071477

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026