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Evaluation and correlation of human salivary biomarker levels before and after application of topical fluoride agents in children with early childhood caries

Evaluation and correlation of salivary matrix metalloproteinase 8 levels before and after application of MI varnish 38 percent silver diamine fluoride and nano silver fluoride in children with early childhood caries an in vivo study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/08/071874
Enrollment
45
Registered
2024-08-02
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: Group 1:Topical application of MI varnish Group 2: Topical application of 38% silver diamine fluoride Group 3: Topical application of nano silver fluoride: MI varnish, 38% Silver diam

Sponsors

Dr Ganavi G Nayak
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Children with 3 to 6 years of age of both the genders 2.Children with DC greater than or equal to 3 in primary teeth , ICDAS II criteria, CODE 02 and 03 3.Parents giving consent for the study.

Exclusion criteria

Exclusion criteria: 1.Children who received fluoride topical application during the last 1 month. 2.Children requiring special health care needs. 3.Pulpally involved and grossly decayed teeth. 4.Children who were on antibiotic therapy within the past 3 months. 5. Children with genetic diseases or syndrome.

Design outcomes

Primary

MeasureTime frame
Evaluate salivary MMP-8 levels before and after application of MI varnish, 38% SDF and NSF in children with ECC using ELISA. Timepoint: Base line 1 month 3 months—

Secondary

MeasureTime frame
Correlation & comparision of intragroup & intergroup salivary MMP- 8 levels before & after application of MI varnish, 38% SDF & NSF in children with ECC using ELISATimepoint: Base line 1 month 3 months—

Countries

India

Contacts

Public ContactDr Ganavi G Nayak

Rajarajeswari dental college and hospital bengaluru

jaya.vrushabh@gmail.com9880038038

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026