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To study role of Transforming growth factor regulator 4 gene in patients of oral red and white lesion and healthy oral tissue.

Analysis Of Genomic And Proteomic Expression Of Transforming Growth Factor ß Regulator 4 In Clinico-Histopathologically Diagnosed Cases Of Oral Leukoplakia And Normal Healthy Mucosa – A Prospective Cross-Sectional Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/08/071863
Enrollment
30
Registered
2024-08-02
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue

Interventions

Intervention1: NIL: NIL

Sponsors

MGM Dental College and Hospital, Navi Mumbai
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group I (control group) 1. Normal patients those who are willing to participate. 2. Age and sex matched cases of healthy oral mucosa 3. Patients undergoing periodontal flap surgeries 4. Patients undergoing 3rd molar Extractions Group II (study group): Histopathological diagnosed cases of oral leukoplakia

Exclusion criteria

Exclusion criteria: Group I (control group) 1. Patients those who are not willing to participate. Group II (study group): 1. White lesions other than clinic-histologically diagnosed leukoplakia cases. 2. Patients undergoing treatment for leukoplakia and OSCC. 3. Patients who are not willing to participate. 4.Patients with other established carcinomas

Design outcomes

Primary

MeasureTime frame
To analyze and compare genomic expression of Transforming growth factor ß regulator 4 (TBRG4) mRNA by q-PCR in clinico-histopathologically diagnosed cases of oral leukoplakia and normal healthy mucosa.Timepoint: within 48 weeks—

Secondary

MeasureTime frame
To immunohistochemically analyze & compare proteomic expression of Transforming growth factor ß regulator 4 (TBRG4) in clinico-histopathologically diagnosed cases of oral leukoplakia & normal healthy mucosa.Timepoint: within 48 weeks—

Countries

India

Contacts

Public ContactDr Kamlesh Dekate

MGM Dental College and Hospital

dr.kamleshdekate@gmail.com919223290372

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026