Comparing the benefits and safety of Metformin and Canthex® for treating dark skin patches in patients of Acanthosis Nigricans

A comparative study on efficacy and safety of metformin versus canthex ® (alpha lipoic acid, biotin, chromium polynicotinate, zinc) in patients with acanthosis nigricans-Randomised controlled trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/071850

Enrollment

Registered

2024-08-02

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L83- Acanthosis nigricans

Interventions

Intervention1: Administration of tablet metformin in acanthosis nigricans patients: Dose 500 mg twice daily Duration 3 months Control Intervention1: Administration of capsule Canthex in acanthosis nig

Eligibility

Inclusion criteria

Inclusion criteria: Clinically diagnosed with acanthosis nigricans and HOMAIR greater than 1.8

Exclusion criteria

Exclusion criteria: Female Patients who are pregnant and lactating. Patients who are already taking some antidiabetic medication Patients with renal compromise Patients with hepatic compromise Drug induced acanthosis nigricans Malignant acanthosis nigricans

Design outcomes

Primary

Measure	Time frame
The primary outcome measures for effectiveness will be improvement of severity of neck lesions and neck texture which is to be measured by quantitative scale of acanthosis nigricans by Burke et alTimepoint: at the end of 3 months	—

Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactDr Ashish Ramchadrarao Deshmukh

MGM institute of health sciences Aurangabad

ashish7557@gmail.com9422213292

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026