Health Condition 1: O- Medical and Surgical Health Condition 2: G938- Other specified disorders of brain Health Condition 3: G968- Other specified disorders of central nervous system
Conditions
Interventions
Intervention1: Intrtaveinous and local administration of specific drugs: to compare intravenous and local administration and study as to which drug is more effective in attenuating the painful stress
Sponsors
Armed Forces Medical College, Pune
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for the study are that the patients should be accepted under ASA Grade 1-3, they should be in the age group of 18 - 70 Years and the surgical procedure shall include any craniotomy including Supratentorial Tumors and Cysts in Supine position.
Exclusion criteria
Exclusion criteria: Exclusion criteria includes Patients having a history of known Allergy to study Drugs, Patients having a Glasgow coma scale of 13 or less, Patients with Bradycardia with heart rate less than 50 beats per minute, Patients having a history of Beta Blocker intake, Patients having Uncontrolled Hypertension, Patients taking any Oral Anticoagulant, Patients having impaired Cardiac, Kidney or Liver functions, Patients having any Hematological or Endocrine disorder and Patients having a Second or Third degree heart block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure, Blood oxygen saturationTimepoint: At Baseline , After administration of study drugs, Before skull pin fixation, After skull pin fixation at 1, 3, 5, 10, 15 and 20 min respectively | — |
Secondary
| Measure | Time frame |
|---|---|
| Hormonal stress response by measuring serum prolactin, serum cortisol & plasma blood sugar levels before & after skull pin fixation in craniotomiesTimepoint: Before Induction of anesthesia & 30 mins after skull pin fixation | — |
Countries
India
Contacts
Public ContactDr Ajit Bharadwaj
Armed Forces Medical College
Outcome results
None listed