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A clinical study to find the duration of postoperative pain relief between two drugs, Dexmedetomidine and Buprenorphine which are given before the surgery through a needle near shoulder in healthy patients undergoing upper limb surgery.

Comparison of the Analgesic Efficacy of Dexmedetomidine and Buprenorphine as adjuvant to 0.5 Percent Levobupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Prospective Randomized Clinical Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/07/071614
Enrollment
120
Registered
2024-07-31
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Buprenorphine, Dose 0.3mg, administered once subcutaneously and duration is 5 minutes: Supraclavicular block will be performed for 5 minutes under Ultrasound guidance using a 23G Quinck

Sponsors

NIRANCHAN RAMANATHAN
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged between 18 to 65 years who are posted for Upper limb surgeries. 2.American Society of Anaesthesiologists (ASA) physical Status I and II patients.

Exclusion criteria

Exclusion criteria: 1.Patients who refuse to give informed written consent. 2.Patients who are medically unstable. 3.Patients with deranged coagulation profile. 4.Patients who are addicted to narcotics. 5.Patients who are allergic to levobupivacaine, ropivacaine, Dexmedetomidine. 6.Pregnant women 7.Patients on opioid medications. 8.Neurological and musculoskeletal disease.

Design outcomes

Primary

MeasureTime frame
Assessment of Visual Analogue Scale (VAS) to calculate the duration of Pain relief. Rescue analgesia will be given when VAS score was more than or equal to 4.Timepoint: Baseline Visual Analogue Score (VAS) is measured from the time patient is admitted at Postoperative ward and every 60 minutes for next 24 hours.—

Secondary

MeasureTime frame
To assess the Onset & Duration of sensory & motor blockade, intraoperative & intraoperative Hemodynamics & Sedation. Timepoint: Onset of sensory blockade is defined by a score of 1 on pinprick response. Onset of motor blockade will be the complete motor paralysis of wrist & hand. Hemodynamic parameters will be monitored using routine monitors used during a Surgery. Baseline is measured from the end of the intervention & every 5 minutes after that for next 30 minutes.—

Countries

India

Contacts

Public ContactNIRANCHAN RAMANATHAN

Tagore Medical College and Hospital

niranchan.ram@gmail.com7550171454

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026