Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Group A- Ketamine-Dexmedetomidine: This group involves infusion of Ketamine and Dexmedetomidine that will be administered intra operatively for cardiac preconditioning of cardiac bio ma
Sponsors
SMS Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Informed written consent for the study 2. All patients will be American Society of Anaesthesiologists physical status II-III. 3. Aged between 18 and 70 years. 4. Weight between 40 and 70 kg. 5. BMI less than 30. 6. New York Heart Association classification of cardiac function II-III, 7. Ejection fraction greater than 40%
Exclusion criteria
Exclusion criteria: 1. Patient should not part of any other study. 2. Non cooperative patient. 3. Patient with history of acute myocardial infarction. 4. Elevated levels of circulating cardiac troponin 5. History of endocrine, metabolic, neurological and psychotic disorder 6. History of previous unusual response to ketamine, dexmedotomidine, fentanyl, propofol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess and compare the Plasma cardiac troponin-I, CK-MB level, serum cortisol level in Ketamine-dexmedetomidine group and fentanyl-propofol groupTimepoint: Blood samples will be drawn before induction, 4 hours after aortic cross clamping and 24 hours after aortic cross clamping. | — |
Secondary
| Measure | Time frame |
|---|---|
| NIlTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Jaskaran Singh Marjara
SMS Medical College
Outcome results
None listed