Effect of Probiotic Supplementation on Metabolic profile and Inflammatory parameters in Prediabetic Obese Patients in A Tertiary Care Hospital: A Double Blind, Randomized, Placebo Controlled Trial

Effect of Probiotic Supplementation on Metabolic Inflammation in Prediabetic Obese Patients in A Tertiary Care Hospital: A Double Blind, Randomized, Placebo Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071576

Enrollment

Registered

2024-07-30

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E669- Obesity, unspecified

Interventions

Intervention1: lactic acid bacillus capsule 120 million spores: 1 capsule, once daily in the morning, after food, for 12 weeks Control Intervention1: Placebo Capsule: 1 capsule, once daily in the morn

Eligibility

Inclusion criteria

Inclusion criteria: Prediabetic patients Obesity patients

Exclusion criteria

Exclusion criteria: Known history of gastrointestinal malabsorption, chronic diarrhoea. Antibiotic consumption or intestinal infection in 3 months Pregnancy, lactation, psychiatric patients

Design outcomes

Primary

Measure	Time frame
Improvement in prediabetic state by estimating FBS, PPBS and HbA1cTimepoint: 12 weeks	—

Secondary

Measure	Time frame
1.Improvement in insulin resistance by estimating TyG index, TG/HDL C ratio 2.Improvement in inflammation – TNF alpha, Malondialdehyde (MDA) 3.Improvement in Quality of life assessed by questionnaire (Shortform Health Survey) SF-36Timepoint: 12 weeks	—

Countries

India

Contacts

Public ContactSathyanarayanan V

SRM Medical College Hospital and Research Centre

sathyanv@srmist.edu.in9384633405

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026