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Effect of nitrous oxide gas on seizure when used with general anaesthesia for electroconvulsive therapy

Effect of Nitrous oxide on seizure threshold when used as an adjunct to intravenous induction of anesthesia in patients undergoing electroconvulsive therapy- A Double Blind Randomized Cross-over Trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/07/071557
Enrollment
40
Registered
2024-07-30
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F31- Bipolar disorder Health Condition 2: F22- Delusional disorders Health Condition 3: F33- Major depressive disorder, recurrent Health Condition 4: F32- Major depressive disorder, singleepisode Health Condition 5: F30- Manic episode Health Condition 6: G- Mental Health Health Condition 7: F30-F39- Mood [affective] disorders Health Condition 8: F28- Other psychotic disorder not due to a substance or known physiological condition Health Condition 9: F25- Schizoaffective disor

Interventions

Intervention1: 50% Nitrous oxide gas with 50% Oxygen: 50% Nitrous oxide gas with 50% Oxygen at the rate of 4-6 lit/minute for 3-5 minutes via anatomical anaesthesia silicon face mask to achieve end ti

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing electroconvulsive therapy Age 18-65 yrs ASA 1 & 2.

Exclusion criteria

Exclusion criteria: Guardian/Legal relative refusal, ASA grade 3 or more, Patients with raised intracranial pressure, Pregnant and Lactating females, COPD patients

Design outcomes

Primary

MeasureTime frame
Effect of nitrous oxide on the stimulus dose required to produce effective seizure in patients undergoing ECT.Timepoint: At the end of ECT—

Secondary

MeasureTime frame
Adverse respiratory eventsTimepoint: End of ECT;Cognitive scoreTimepoint: End of ECT;Duration of post ictal stateTimepoint: End of ECT;Nausea and vomitingTimepoint: End of ECT;Seizure duration(Motor/EEG).Timepoint: End of ECT—

Countries

India

Contacts

Public ContactDR APARAJITA PANDA

AIIMS, Sijua, Bhubaneswar

devadathkr@gmail.com9048441400

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026