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To explore the link between the ratio of CRP to albumin in serum and the ratio of neutrophils to lymphocytes (NLR), along with Tau protein levels, in postoperative cognitive dysfunction in patients having oncological surgeries.

Tau protein, Neutrophil-to lymphocyte ratio, C-Reactive Protein to albumin as predictive tools for post-operative cognitive dysfunction in oncosurgical patients : In single centre study: a Prospective observational study. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/07/071476
Enrollment
90
Registered
2024-07-29
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D499- Neoplasm of unspecified behavior of unspecified site

Interventions

Intervention1: Blood investigation to be done after admission of pateints: Blood investigation neutrophils lymphocytes ratio, CRP albumin ratio, and tau protein will done prior to surgery and after th

Sponsors

Swami Rama Himalayan university
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I, II and III. 3. Scheduled for oncological surgeries under anesthesia. 4. Ability to provide written informed consent

Exclusion criteria

Exclusion criteria: ASA grade IV Patients and Emergency surgeries. 2. Refusal or contraindication for general surgery. 3. History of neurological or psychiatric disorders. 4. Active infection. 5. History of alcohol or drug abuse. 6. Surgery not more than 4 hours. 7. Dementia and Cognitive impairment. 8. Patients with severe neuropsychiatric Disease. 9. Patients who underwent surgery during last 6th months. 10.History of Hypotension. 11. Patients with severe heart, lung, Brain, liver and kidney function abnormalities. 12.Duration of surgery less than 4 hours.

Design outcomes

Primary

MeasureTime frame
To determine the levels of serum CRP, albumin, NLR, and Tau protein preoperative in cancer patients who develop Post operative delirium compared to those who do not develop Post operative delirium. 2. To examine the correlation between serum CRP to albumin ratio, Neutrophil to lymphocyte ratio, Tau protein levels preoperatively and the severity and duration of Post operative delirium in elderly cancer patients. 3. To determine the predictive value of serum CRP, albumin, Neutrophil to lymphocyte ratio, and Tau protein levels preoperatively for the development of POD in cancer patients undergoing surgery.Timepoint: 1.preoperative evaluation of Postoperative Cognitive dysdunction 2. 12th hours after extubation evaluation of Cognitive Function 3. 1 day after extubation 4. 2nd post operative day 5. 3rd post operative day 6. every day untill dischage of the patient. 7. after 3 months of Operation.—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactDr Veena Asthana

Himalayan Institute of medical sciences, jollygrant dehradun

veenaasthana@srhu.edu.in9719529195

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026