Health Condition 1: L281- Prurigo nodularis Health Condition 2: L281- Prurigo nodularis
Conditions
Interventions
Intervention1: Cyclosporine: The patients meeting all the inclusion criteria will participate in this study
A detailed history including the duration of disease, associated medical conditions, treatm
Sponsors
IMS and SUM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients with more than equal to 18 years age group, diagnosed clinically and histopathologically as prurigo nodularis and having with severe pruritus for at least 3 months Severe pruritus was defined as a mean score of at least 7 points over the previous week for the worst daily intensity of pruritus on the numerical rating scale Patients having an active health insurance.
Exclusion criteria
Exclusion criteria: 1. chronic pruritus due to conditions other than PN; 2. use of antihistamines, steroids, other systemic antipruritic therapies, or immunosuppressants 1 to 2 weeks before the baseline visit; 3. recent phototherapy; 4. use of medications known to induce pruritus; serum creatinine level higher than 2.4 mg/dL; 5. aspartate transaminase or alanine transaminase levels more than 2 times the upper limit of normal; 6. Active infection(HIV, Tuberculosis, Hepatitis b,etc) 7. Latent tuberculosis 8. Known case of dyslipidemia 9. Prior history of MI, cerebral ischaemia and transient ischaemic attack. 10. History of prior venous thromboembolism, major surgery and immobolisation in past 6 months. 11. On concurrent oral contraceptive pills or hormone replacement therapy. 12. Patient have any inherited coagulation disorder. 13. Pregnant and lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in Investigator global assessment score for chronic nodular prurigo Worst itch numerical rating score(WI -NRS) DLQI, Dermoscopic evaluation Photographic evaluation Timepoint: 4 weekly | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in Disease life quality index will be assessed in both groups Timepoint: Assessment will be done 4weekly during followup | — |
Countries
India
Contacts
Public ContactSubhasree Madhual
IMS AND SUM HOSPITAL
Outcome results
None listed