Hemodynamic instability comparison between prazosin and amlodipine in PPGL(pheochromocytoma and paraganglioma)

Comparative analysis of Pre-operative Prazosin versus Am-lodipine on Intraoperative Hemodynamic Instability in Patients with Pheochromocytoma/Paraganglioma (PPGL): An Open-label Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071431

Enrollment

Registered

2024-07-26

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E368- Other intraoperative complicationsof endocrine system

Interventions

Intervention1: AMLODIPINE: Tablet Amlodipine will be started at the dosage of 2.5 mg once daily per oral and up-titrated at dose of 2.5 mg increments daily up to 10 mg in two divided doses then in i

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age- 18-65 years 2. Secretory PPGL - Elevated plasma-free meta-nephrine and or plasma-free normetanephrine irre-spective of Blood pressure recordings 3. Planned for surgical removal

Exclusion criteria

Exclusion criteria: 1. Bilateral tumour 2. Distant metastasis 3. Pregnancy 4. Incapability to adhere to study protocol

Design outcomes

Primary

Measure	Time frame
To determine the efficacy of amlodipine in reducing the intra-operative hemodynamic instability duration (%) in patients with PPGL compared to prazosinTimepoint: At the end of surgery	—

Secondary

Measure	Time frame
To determine the efficacy of amlodipine in reducing the intraoperative hemodynamic instability score in patients with PPGL compared to prazosin To study Ambulatory blood pressure monitoring (ABPM ) characteristics pre-operatively & hemo-dynamic instability post-operatively in patients with PPGL To identify the factors influencing hemodynamic in-stability during the peri-operative period Timepoint: At the end of 24 hours after surgery	—

Measure

Time frame

To determine the efficacy of amlodipine in reducing the intraoperative hemodynamic instability score in patients with PPGL compared to prazosin To study Ambulatory blood pressure monitoring (ABPM ) characteristics pre-operatively & hemo-dynamic instability post-operatively in patients with PPGL To identify the factors influencing hemodynamic in-stability during the peri-operative period Timepoint: At the end of 24 hours after surgery

—

Countries

India

Contacts

Public ContactSadishkumar kamalanathan

Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER),PONDICHERRY

sadishkk@gmail.com9629528518

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026