Health Condition 1: J80- Acute respiratory distress syndrome
Conditions
Interventions
Intervention1: SUSTAINED HYPERINFLATION TECHNIQUE:
: Patients who are orally intubated and mechanically ventilated,sedated with a Propofol–fentanyl combination and
paralyzed with Atracurium.
Ventilat
Sponsors
Institute Of Liver And Biliary Sciences Vasnt KunjNew Delhi
Eligibility
Inclusion criteria
Inclusion criteria: All chronic liver disease patients and ACLF patients. • Body mass index = 35 kg/m2 • Hypoxemic patients with PaO2/FiO2 ratio measured by blood gas analysis of 150 to 200.
Exclusion criteria
Exclusion criteria: • Pregnancy • COPD • Increased intracranial pressure. • Unstable spine or pelvic fractures • Patients with Pacemaker and Automatic implantable cardio-defibrillator • Hemodynamic instability defined as persistent mean arterial pressure lower than 60 mm Hg despite adequate fluid resuscitation and two vasopressors or increase of vasopressor dose by 30% in the previous 6 hours. • Patients with large pleural effusions and Intercoastal drains.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| :To compare the physiological effects of the two recruitment maneuvers on the oxygenation (PaO2/FiO2 ratio) after 30 minutesTimepoint: 30 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the effect of recruitment maneuver on ? Pulmonary mechanics – Compliance, Peak airway pressure, plateau pressure,Paco2,Spo2. ? Haemodynamics – Systolic Blood Pressure, Diastolic blood pressure,Mean arterial pressure ? USG Scores of Lung – at baseline and 30 minutes after recruitment. ? Proportion of patients whose P/F ration improved above 300 Timepoint: 30 minutes | — |
Countries
India
Contacts
Public ContactSahithi Latha Ronanki
Institute Of Liver And Biliary Sciences
Outcome results
None listed