A randomized study to compare the effect of low-dose Ketamine versus Fentanyl on the hemodynamic response to laryngoscopy and endotracheal intubation.

A randomized study to compare the effect of low-dose Ketamine versus Fentanyl on the hemodynamic response to laryngoscopy and endotracheal intubation in Department of Anaesthesiology, SMS Medical College and Attached Hospitals, Jaipur . - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071287

Enrollment

Registered

2024-07-25

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Ketamine: 0.5 mg/kg Ketamine intravenously giving only once before 3 minutes of anaesthesia Control Intervention1: Fentanyl: 1 microgram/kg Fentanyl intravenously giving only once befor

Eligibility

Inclusion criteria

Inclusion criteria: Elective Surgery under General Anaesthesia Patient willing to give informed and written consent Age group between 18-50 ASA grade 1&2

Exclusion criteria

Exclusion criteria: 1. History of allergy or contraindications of any study drug 2. Patients scheduled for emergency surgery 3. Hypertension - known or previously dignosed 4. Pregnancy 5. Dementia or psychiatric illness 6. Known Ischemic heart disease 7. Raised intracranial pressure or intracranial pathology where a rise in intracranial pressure would pose a risk or patients scheduled for neurosurgical procedures 8. History or indicator of or proven difficult ventilation or laryngoscopy or intubation Intubation time more than 30 seconds or repeated attempts at intubation 9

Design outcomes

Primary

Measure	Time frame
HypertensionTimepoint: At baseline when patient comes to Operation theatre, post induction- within 1 minute of giving induction agent, during laryngoscopy, just after intubation and at 2, 4, 6, 8,10 minutes interval after intubation	—

Secondary

Measure	Time frame
Tachycardia , post induction hypotension & any side effectsTimepoint: At baseline, post induction, during laryngoscopy, just after intubation & for 10 minutes at 2 minutes interval	—

Countries

India

Contacts

Public ContactAmbili TP

SMS Medical College

trishala.jain31@gmail.com9414281744

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026