To compare efficacy and safety of continuous and intermittent Ryles tube feeding in critically ill patients in terms of achieving target nutrition goal and tolerance of feed.

Continuous versus intermittent enteral tube feeding for critically ill patients A prospective randomized comparative trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071278

Enrollment

120

Registered

2024-07-25

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R69- Illness, unspecified

Interventions

Control Intervention1: Continuous enteral tube feeding: Starting enteral feed 25ml/hour, for 20 hours a day and increasing feed till target nutrition goal is achieved. Control Intervention2: Intermitt

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients 18 to 80 years admitted to the intensive care unit (MEDICAL ICU) 2.Patients receiving mechanical ventilation,who expected to require ventilation for greater than or equal to72 hrs and where to start enteral tube feeding with in 48 hrs of the icu admission. 3.Hemodynamically stable patients. 4.BMI is 18 to 50 5.Patient’s relative giving consent

Exclusion criteria

Exclusion criteria: 1.Patients with contraindications to enteral feeding, such as severe diarrhea greater than one litre in 24hrs,acute pancreatitis,bowel ischemia,bowel obstruction,history of upper GI surgery,malabsorption syndrome,GI bleeding,short bowel syndrome. 2.Pregnancy or lactation. 3.Presence of a percutaneous endoscopic gastrostomy (PEG) or jejunostomy tube. 4.Anticipated need for surgical intervention during the study period. 5.Hypersensitivity reactions to prokinetic agents 6.Abdominal surgery with in one month. 7.Difficulty in placement of nasogastric or orogastric tube. 8.Ongoing enteral nutrition on admission to MICU. 9.Patient’s relatives not giving consent

Design outcomes

Primary

Measure	Time frame
The primary outcome will be Mean duration to achieve at least 70% of the target nutrition requirement after the start of enteral feeding(in hours). The achievement rate will be calculated as the number of days in which at least 70% of the target nutrition requirement is achieved divided by the total number of days of feeding days. Gastrointestinal intolerance during the first 7 days after the start of enteral feedingTimepoint: Enteral feeding will be initiated with in 48 hours of ICU admission after randomization.Target nutrition will be achieved as early as possible and study will monitor patient for seven days for target achieved.	—

Measure

Time frame

The primary outcome will be Mean duration to achieve at least 70% of the target nutrition requirement after the start of enteral feeding(in hours). The achievement rate will be calculated as the number of days in which at least 70% of the target nutrition requirement is achieved divided by the total number of days of feeding days. Gastrointestinal intolerance during the first 7 days after the start of enteral feedingTimepoint: Enteral feeding will be initiated with in 48 hours of ICU admission after randomization.Target nutrition will be achieved as early as possible and study will monitor patient for seven days for target achieved.

—

Secondary

Measure	Time frame
Secondary endpoints will include ICU mortality, 28-day mortality, length of stay in the ICU and hospitalTimepoint: Secondary endpoints will include ICU mortality, 28-day mortality, length of stay in the ICU and hospital	—

Countries

India

Contacts

Public ContactDR VAIBHAV BHARGAVA

FORTIS ESCORTS HOSPITAL,JAIPUR

drvaibhav79@gmail.com9928787788

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026