A clinical trial to study the reduction in pain and redness of gums with additional use of Grapefruit seed and Pomegranate extract mouth rinse along with local application of steroids in patients with red, burning and ulcerated gums associated with Oral Lichen Planus.

Effectiveness of Grapefruit seed and Pomegranate extract based mouth rinse as an adjunctive treatment modality in the management of desquamative gingivitis associated with Oral Lichen Planus: A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071239

Enrollment

Registered

2024-07-25

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K137- Other and unspecified lesions of oral mucosa

Interventions

Intervention1: Grapefruit seed and Pomegranate extract based mouth rinse along with 0.1% triamcinolone acetonide oral paste: Topical application of 0.1% triamcinolone acetonide oral paste(Kenacort) b

Eligibility

Inclusion criteria

Inclusion criteria: Patients with clinical or histopathological diagnosis of Oral Lichen Planus (OLP) with desquamative gingivitis.

Exclusion criteria

Exclusion criteria: Patients already under topical or systemic corticosteroid medications for Oral Lichen Planus. Patients with systemic diseases causing oral ulcerations like- gastrointestinal disorders. Patients who are receiving or have received Chemotherapeutic drugs, Immunomodulators and topical or systemic Corticosteroids in the recent 1 year. Pregnant and lactating mothers. Patients with known allergy or contraindications to study medications.

Design outcomes

Primary

Measure	Time frame
1. Desquamative Gingivitis Clinical Score (0,1,2,3,4) to assess healing outcome of the lesion. 2.Visual Analogue Scale (0 to 10)- to assess reduction in pain perceptionTimepoint: Baseline, 2 weeks post intervention, 4 weeks post intervention	—

Secondary

Measure	Time frame
To evaluate the presence of side effects during the course of treatment.Timepoint: Baseline, 2 weeks post intervention, 4 weeks post intervention	—

Countries

India

Contacts

Public ContactDr Ankitha Miriya Alias

Government Dental College, Kottayam

drphilipsmathew@gmail.com7907411361

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026