Health Condition 1: K729- Hepatic failure, unspecified
Conditions
Interventions
Intervention1: Human albumin intravenous infusion: Dose: 20gram (20% Albumin)
Frequency: Once/Twice a day
Route of Administration: Intravenous Slow Infusion
Total Duration: For 5 days after the liver transplant surgery
Control Intervention1: No human albumin intravenous infusion: None
Control Intervention2: Placebo infusion (Normal Saline): Dose: 100-200m
Total Duration: For 5 days after the liver transplant surgery
Sponsors
Dr Subhash Gupta
Eligibility
Inclusion criteria
Inclusion criteria: Immediate post living donor liver transplant recipients (Aged greater than 18 years) admitted to the liver transplant intensive care unit
Exclusion criteria
Exclusion criteria: 1)Pregnancy, 2)Age less than 18 years, 3)Re-transplantation, 4)Deceased donor LT, 5)Greater than 3 organ failure (ACLF grade 3), 6)Pre LT rapid filling ascites or Grade 3 ascites, 7)Primary graft failure, 8)Post LT vascular or biliary complication, 9)Negative consent, 10)Post LT correction of hypoalbuminemia (Sepsis, Hemodynamic instability, acute kidney injury), 11)Graft weight less than 600 grams, 12)Combined liver-kidney transplant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome is to determine if correcting hypoalbuminemia with albumin infusion in post LT period, helps in decreasing the surgical drain output by 20% on post operative day 5Timepoint: Post Transplant Day 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the incidence of serious adverse events till dischargeTimepoint: Discharge date | — |
Countries
India
Contacts
Public ContactVipul Gautam
Max centre for liver and biliary sciences
Outcome results
None listed