To compare 2 In vitro fertilization protocols in patients with bad response

To compare the efficacy of SANDWICH (delayed start GnRH antagonist) protocol with conventional antagonist stimulation protocol in terms of IVF outcomes in POSEIDON poor responders: A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071223

Enrollment

Registered

2024-07-24

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N979- Female infertility, unspecified

Interventions

Intervention1: SANDWICH protocol for poor responders in infertility: Patients will receive Tab.Estradiol valerate (Tab Estrabet) 2mg twice a day orally for 10 days from midluteal phase (day 21) of pre

Eligibility

Inclusion criteria

Inclusion criteria: Poseidon poor responders from age 19 years to 40 years

Exclusion criteria

Exclusion criteria: Anatomical and pathological abnormalities in the uterus Endocrine disorders such as thyroid dysfunction, hyperprolactinemia and diabetes mellitus h/o tumour in hypothalamus and pituitary, Hypogonadotropic hypogonadism Azoospermia in male partner Endometriosis, h/o previous adnexal surgeries Recurrent miscarriage and recurrent implantation failure BMI = 30

Design outcomes

Primary

Measure	Time frame
Number of oocytes retrievedTimepoint: 40 days	—

Secondary

Measure	Time frame
Total dose of gonadotrophins required Duration of controlled ovarian stimulation Peak serum estradiol (E2) & progesterone (P4) on the day of trigger FORT/Follicular output rate Endometrial thickness on the day of OPU Number of mature oocytes (MII) retrieved Fertilization rate Cleavage rate Total number of embryos Embryo grading Cycle cancellation rate Clinical pregnancy rate per embryo transfer Live birth rate (LBR) Miscarriage rate Timepoint: 40 days	—

Measure

Time frame

Total dose of gonadotrophins required Duration of controlled ovarian stimulation Peak serum estradiol (E2) & progesterone (P4) on the day of trigger FORT/Follicular output rate Endometrial thickness on the day of OPU Number of mature oocytes (MII) retrieved Fertilization rate Cleavage rate Total number of embryos Embryo grading Cycle cancellation rate Clinical pregnancy rate per embryo transfer Live birth rate (LBR) Miscarriage rate Timepoint: 40 days

—

Countries

India

Contacts

Public ContactDr Neeta Singh

AIIMS New Delhi

drneetasingh@yahoo.com9818506855

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026