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Comparison of inhaled Dexmedetomidine ( this is a drug used to manage pain and sedation in the icu and operating theatre) and Lignocaine (this is a drug used to prevent pain) on blood pressure, heart rate, oxygen saturation during intubation.

Comparative evaluation of nebulised Dexmedetomidine and Lignocaine on haemodynamic stress response to laryngoscope and intubation - A prospective, randomized clinical study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/07/071191
Enrollment
90
Registered
2024-07-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulized Dexmedetomidine: Patient Will be receiving nebulized Dexmedetomidine 1 microgram per kg mixed with saline to a total volume of 5ml Control Intervention1: Nebulized Lignocaine

Sponsors

Dr Tridha Ghosh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patient giving consent to participate in study 2) Age between 18-60yrs 3) American Society of Anaesthesiologist Grade 1 & 2

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
1) Dexmedetomidine (1microgram/kg) serves as a very useful anaesthesia adjuvant to control haemodynamic stress response to laryngoscope and intubation without any significant adverse effects. 2) Efficacy of nebulized dexmedetomidine in attenuation of the haemodynamic stress response compared to nebulized Lignocaine will be significantly higer in ASA-1 and 2 Patients with respect to HR, SBP, DBP and MAP. Timepoint: These outcomes are based on observations made after giving nebulized drugs 10 minutes before intubation to 90th minutes intraoperatively.—

Secondary

MeasureTime frame
Nebulized Lignocaine also attenuated the haemodynamic stress response during intubation and laryngoscopy compared to normal saline.Timepoint: These outcomes are based on observations made after giving nebulized drugs 10 minutes before intubation to 90th minutes intraoperatively.—

Countries

India

Contacts

Public ContactDr Jitendra Agrawal

Gajra Raja Medical College, Gwalior,Madhya Pradesh

drjagrawal@gmail.com9300009942

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026