A study to compare the effect of microneedling with 2 medications, Tranexamic acid and Vitamin C, for reducing the skin pigmentation in patients with melasma.

A split-face comparative study assessing the efficacy of microneedling with Tranexamic acid vs microneedling with Vitamin C in the treatment of melasma. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071158

Enrollment

Registered

2024-07-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L811- Chloasma

Interventions

Intervention1: Microneedling with Tranexamic acid and Microneedling with Vitamin C in a split-face manner: Microneedling with Tranexamic acid over the right side of the face and Microneedling with Vit

Eligibility

Inclusion criteria

Inclusion criteria: Females aged 18 years and above with Melasma over bilateral sides of the face.

Exclusion criteria

Exclusion criteria: Male gender. Pregnant women, breastfeeding mothers. History of use of oral contraceptive pills or hormone replacement therapy in the past 12 months or during the study. History of coagulation disorders and thrombotic problems. History of use of topical depigmenting agents within the last 60 days of the study. Presence of active infection over the face. Presence of keloidal tendency.

Design outcomes

Primary

Measure	Time frame
Reduction in MASI scoreTimepoint: 2, 4, 6 , 8 weeks	—

Secondary

Measure	Time frame
Patient satisfactionTimepoint: 2 , 4, 6 ,8 weeks	—

Countries

India

Contacts

Public ContactVarsha Reddy Parupati

Sri Ramachandra Institute for Higher Education and Research

murug1972@gmail.com9790954956

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026