Health Condition 1: I739- Peripheral vascular disease, unspecified
Conditions
Interventions
Intervention1: Melatonin: Patient will receive melatonin 3mg on two consecutive evenings, on the evening before surgery and one day prior to the day before surgery (at seven p.m.).
Control Interventio
Sponsors
Dr Basudev Pati
Eligibility
Inclusion criteria
Inclusion criteria: All patients in the age group of 40 to 75 years of age undergoing reperfusion surgery or bypass procedure for chronic limb ischaemia. The bypass procedure could be aorto-femoral, femoro-popliteal or aorto-femoro-popliteal bypass.
Exclusion criteria
Exclusion criteria: Patients with known psychiatric disorders. Pychotropic drugs consumption. Patients on anticonvulsants. History of ongoing substance abuse. Severe anemia. Severe copd or asthma. CKD stage 3 and above. History of cerebrovascular disease. Sensory disorders including blindness,hearing loss, cognitive disorders and dementia. Patients not extubated on the table and reintubated within the duration of study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To report the incidence of delirium between melatonin and placebo group.Timepoint: post operative day 1 till post operative day 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of delirium. Severity of delirium. Length of hospital stay. Total dose of haloperidol and benzodiazepines administered during delirium. In hospital mortality rate. ICU admittance and length of stayTimepoint: 5 days or 120 hours | — |
Countries
India
Contacts
Public ContactDr Sanjay Kumar Jaswal
PGIMER,Chandigarh
Outcome results
None listed