Comparative trial to know the efficacy of combined voriconazole and gatifloxacin vs monotherapy of either for the treatment of microsporidial keratoconjunctivitis

A randomized trial to compare the efficacy of combined voriconazole and gatifloxacin therapy versus monotherapy with either drug in the treatment of microsporidial keratoconjunctivitis - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/071124

Enrollment

Registered

2024-07-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H162- Keratoconjunctivitis

Interventions

Intervention1: Combination of topical voriconazole 1% and gatifloxacin 0.5%: Both topical voriconazole 1% and gatifloxacin 0.5% will be given every one hourly on day 1 and based on the response, the d

Eligibility

Inclusion criteria

Inclusion criteria: 1. Gram staining or laboratory proven microsporidial keratitis (MKC) 2. Any age group who could cooperative for corneal scraping

Exclusion criteria

Exclusion criteria: 1.Microsporidial stromal keratitis 2.Laboratory negative SPKs 3.Uncoperative patient or not willing for follow up

Design outcomes

Primary

Measure	Time frame
1. SPKs 2. Corneal haziness grading Timepoint: 1 day, 3 days and weekly	—

Secondary

Measure	Time frame
1. resolution of Conjunctival redness 2.Improvement in Visual acuity (UAVA and BCVA) 3.normalisation of Intraocular pressure if elevated 4.decrease in Eye lid swelling Timepoint: 1 day, 3 days and weekly	—

Countries

India

Contacts

Public ContactBalamurugan Ramatchandirane

AIIMS Mangalagiri

bala16690@yahoo.co.in07087796565

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026