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An in vitro investigation to assess the osteoanabolic effects of doxycycline in a proteosomal gel form.

Evaluation of Osteoanabolic effect of Doxycycline Proniosomal gel form : An invitro study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/07/071118
Enrollment
2
Registered
2024-07-23
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Dr Vaishnavi Langde self
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Healthy dental pulp mesenchymal stem cells procured from healthy non carious extracted tooth.

Exclusion criteria

Exclusion criteria: NIL

Design outcomes

Primary

MeasureTime frame
Invitro evaluation of the biological behavior of doxycycline proniosomal gel for their use as bone regenerative material.Timepoint: 1,2and 6 months—

Secondary

MeasureTime frame
1. To evaluate the cytotoxic effect of doxycycline proniosomal gel on pulpal dental stem cells by MTT assay. 2. To study the osteogenic differentiation potential of doxycycline proniosomal gel in mesenchymal stem cells by alizarin red staining. 3. To investigate the osteogenic gene expression such as alkaline phosphatase and osteonectin for osteogenic differentiation. Timepoint: 1,2 and 6 months—

Countries

India

Contacts

Public ContactDr Dhawal Mody

Ranjeet Deshmukh Dental College and Research Centre

periowell@gmail.com8055775977

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026