Health Condition 1: E031- Congenital hypothyroidism withoutgoiter
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Heart Rate Variability: Heart rate variability analysis is a measure of autonomic dysfunctions manifested as sympathovagal imbalance in humans. It is a n
Sponsors
Maulana Azad Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Case: Children of age group 8- 18 years with primary hypothyroidism maintaining euthyroid status on L-thyroxine therapy for at least 6 months. Controls: Age and gender matched apparently healthy children who are euthyroid of age group 8-18 years.
Exclusion criteria
Exclusion criteria: 1. Undergoing structured physical activity regime over last 3 months. 2. Fever or systemic illness requiring hospitalization in preceding 4 weeks. 3. Previously diagnosed hypertension, renal disease or cardiovascular disease. 4. Any other associated endocrinal disorder like diabetes, adrenal disorders. 5. On any drug which might affect heart rate like beta blockers/ agonists/ calcium channel blockers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean difference in heart rate variability of cases and controls. Timepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean difference in beat-to-beat variability in cases and controls. Association of sleep/wake cycle with Continuous Ambulatory Blood Pressure Monitoring in cases. Proportion of cases with abnormal Continuous Ambulatory Blood Pressure records. Correlation of Heart Rate Variability, mean Systolic Blood Pressure and Diastolic Blood Pressure with fT3, fT4 and TSH levels and disease duration.Timepoint: Baseline | — |
Countries
India
Contacts
Public ContactDr Aashima Dabas
Maulana Azad Medical College
Outcome results
None listed