Health Condition 1: A519- Early syphilis, unspecified
Conditions
Interventions
Intervention1: Injection Ceftriaxone: Injection Ceftriaxone 1 gram Intravenously for 10 days
Control Intervention1: Injection Benzathine Penicillin: Single Dose of Injection Benzathine Penicillin 2.4
Sponsors
Government Tirunelveli Medical College
Eligibility
Inclusion criteria
Inclusion criteria: All patients who present in STD Clinics with untreated Early syphilis (Includes Primary, Secondary and Early latent syphilis). Operational definition for Early syphilis – 1 year from the primary lesion(chancre) or if there is no primary chancre 1 year from the date of last contact with REACTIVE RPR & Confirmed by POSITIVE TPHA
Exclusion criteria
Exclusion criteria: 1. Positive skin-test reaction to penicillin antigen and ceftriaxone antigen 2. History of penicillin and ceftriaxone allergy 3. Patients who have received any other antibiotics before initiation of treatment 4. Patients with Late latent syphilis and Tertiary syphilis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serological response as defined as a four fold decrease in the initial RPR titre within 6 months of treatmentTimepoint: Serological response as defined as a four fold decrease in the initial RPR titre within 6 months of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing the time taken for RPR to fall in both groups and to monitor for Adverse events if any in both groupsTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactDr Briswin Jino B G
Government Tirunelveli Medical College
Outcome results
None listed