A Comparative Study of Inflammation in Gum Fluid After Using Two Dental Treatments for Severe Tooth Pain

Comparative evaluation of inflammatory biomarkers in gingival crevicular fluid after Mineral Trioxide Aggregate and Biodentine pulpotomy in teeth with Symptomatic Irreversible Pulpitis: An Open label Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070985

Enrollment

Registered

2024-07-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: pulpotomy using biodentine as a pulpotomy agent: second group will be intervened by biodentine as a pulpotomy agent ,outcome is assessed by change in inflammatory marker levels after 7

Eligibility

Inclusion criteria

Inclusion criteria: Patient age 18 -60 years.Non contributory medical history (ASA1),Deep caries extending to pulp chamber.Vital mature first mandibular molar with symptoms of irreversible pulpitis.Tooth with positive response to pulp sensibility testing. Clinical diagnosis of irreversible pulpitis with PAI score=2.Tooth should be restorable.Tooth with probing pocket depth and mobility should be within normal limits.

Exclusion criteria

Exclusion criteria: Teeth with immature roots.Teeth with clinical sign of pulp necrosis such as swelling or presence of sinus tract .Teeth with prominent radiolucency in the furcation area, presence of internal or external root resorption, any calcification.Teeth with no evidence of bleeding after communication with pulp chamber. Absence of antagonist tooth. Had taken analgesic in past 3 days or antibiotic in past one month.Tooth with periapical lesion visible on radiograph. Teeth in which hemostasis was not achieved in 10 min.

Design outcomes

Primary

Measure	Time frame
primary outcome : evaluate change in inflammatory marker before and after pulpotomy Timepoint: 7 days	—

Secondary

Measure	Time frame
secondary Outcome assessment criteria to be performed every 3, 6 and 12 months : Clinical criteria: 1. Post operative pain assessment using VAS after 24, 48, 72 hours and 7 days. 2. No history of spontaneous pain or discomfort except for the first 2 days after treatment 3. No tenderness to palpation or percussion and the tooth is functional 4. Normal mobility and probing pocket depth 5. Soft tissues around the tooth are normal with no swelling or sinus tract Radiographic criteria: 1. No pathosis evident on the radiograph such as periapucal widening, root resorption, furcal pathosis or new periapical pathosis . Timepoint: 12 months	—

Measure

Time frame

secondary Outcome assessment criteria to be performed every 3, 6 and 12 months : Clinical criteria: 1. Post operative pain assessment using VAS after 24, 48, 72 hours and 7 days. 2. No history of spontaneous pain or discomfort except for the first 2 days after treatment 3. No tenderness to palpation or percussion and the tooth is functional 4. Normal mobility and probing pocket depth 5. Soft tissues around the tooth are normal with no swelling or sinus tract Radiographic criteria: 1. No pathosis evident on the radiograph such as periapucal widening, root resorption, furcal pathosis or new periapical pathosis . Timepoint: 12 months

—

Countries

India

Contacts

Public ContactDr Ranjana Hanumant Deshmukh

All India Institute of Medical Sciences ,Nagpur

drneelamch@gmail.com9323218572

Outcome results