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Effectiveness of drugs in hemodynamic changes during laryngoscopy and intubation in patients undergoing surgey under General Anaesthesia.

To compare the efficacy of oral Melatonin, Gabapentine, Clonidine and Placebo in attenuating hemodynamic response during laryngoscopy and intubation in patients undergoing surgery under General Anaesthesia , A four armed Randomized Double blinded clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/07/070958
Enrollment
80
Registered
2024-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: oral drugs attenuating hemodynamic response during laryngoscopy and intubation: All patients will be subjected to routine pre-anesthetic checkup in the preoperative period. All routine

Sponsors

Department of Anaesthesia
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients within ASA Grade 1 and 2 2 Patients in the age of 20-60 yrs 3 Elective surgeries under GA with endotracheal intubation

Exclusion criteria

Exclusion criteria: 1 Patients with anticipated difficult airway 2 Pregnant patients 3 Patients on antipsychotics ,sedatives ,anxiolytics and antiepileptics 4 Patients refusal to give consent.

Design outcomes

Primary

MeasureTime frame
Assessment of hemodynamic changes during laryngoscopy and intubation and after extubationTimepoint: During laryngoscopy and intubation first 1 min ,2nd min ,3rd min ,4th min and post extubation 10 min—

Secondary

MeasureTime frame
To assess the requirement of injection propofol for Propofol for induction and requirement of isoflurane during intraoperative periodTimepoint: Till surgery get over—

Countries

India

Contacts

Public ContactDr Shilpa Masur

Department of Anaesthesia ,S.Nijalingappa Medical College and HSK hospital ,Bagalkot 587102

rashmibiradar28@gmail.com9844117959

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026