A study comparing a gel containing 5 percent melatonin with platelet rich fibrin versus just platelet rich fibrin for treating bony defects a study using clinical and radiographic exam.

Comparative evaluation of 5 percent Melatonin gel in combination with Platelet rich Fibrin and Platelet Rich Fibrin alone in the treatment of Intrabony defects: A Clinico-Radiographic Study. - Nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070947

Enrollment

Registered

2024-07-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: 5% melatonin in combination with PRF: One time 0.5-1 mL Local drug delivery at the site of intrabony defect. Control Intervention1: Standard Control: PRF- single time at the site of int

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients with stage III periodontitis assessed by probing pocket depth (PPD) = 6mm, interdental clinical attachment loss (CAL) = 5mm. 2) Patients with intrabony defects in either maxillary or mandibular arch.

Exclusion criteria

Exclusion criteria: 1) Patients with history of systemic diseases, allergies or drug usage. 2) Patients who have undergone periodontal treatment in previous 6 months. 3) Pregnant or lactating women. 4) Smokers, tobacco chewers and patients with poor oral hygiene index will be excluded from the study. 5) In addition, tooth with caries, mobility greater than grade II will be excluded.

Design outcomes

Primary

Measure	Time frame
Bone fillTimepoint: Baseline, 3 and 6 months.	—

Secondary

Measure	Time frame
1) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intrabony defects when treated with 5% Melatonin gel in a combination with PRF at baseline, 3 months and 6 months postoperatively. 2) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intrabony defects when treated with PRF alone at baseline, 3 months and 6 months postoperatively. 3) To assess radiographic bone fill obtained in intrabony defects when treated with 5% Melatonin gel in a combination with PRF at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). 4) To assess radiographic bone fill obtained in intrabony defects when treated with PRF alone at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). Timepoint: Baseline, 3 and 6 months.	—

Measure

Time frame

1) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intrabony defects when treated with 5% Melatonin gel in a combination with PRF at baseline, 3 months and 6 months postoperatively. 2) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intrabony defects when treated with PRF alone at baseline, 3 months and 6 months postoperatively. 3) To assess radiographic bone fill obtained in intrabony defects when treated with 5% Melatonin gel in a combination with PRF at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). 4) To assess radiographic bone fill obtained in intrabony defects when treated with PRF alone at baseline and 6 months post operatively by Cone Beam Computed Tomography (CBCT). Timepoint: Baseline, 3 and 6 months.

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Countries

India

Contacts

Public ContactDr. Surekha Rathod

Ranjeet Deshmukh Dental College and Research Centre, Nagpur.

drsurekhar@gmail.com9011071477

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026