Health Condition 1: - Health Condition 2: B968- Other specified bacterial agents as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: NIL: NA
Control Intervention1: NIL: NA
Sponsors
Amit Kumar
Eligibility
Inclusion criteria
Inclusion criteria: All children between 1 yr-18 years of age admitted in Paediatric intensive care unit with a diagnosis of sepsis/septic shock
Exclusion criteria
Exclusion criteria: A. Children less than 1 year of age B. Traumatic brain injury C. CNS malformation D. CNS malignancy E. Children with seizure disorder F. Cerebral palsy G. Global developmental delay H. Sickle cell disease I. Severe acute malnutrition J. Congenital heart disease K. Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To categorize the cerebral flow velocity phenotypes derived from transcranial doppler in children with sepsis.Timepoint: TCD measurements will be done at 1. Within 6 hours of PICU admission 2. At 12 hours of PICU admission 3. At 24 hours of PICU admission 4. At 48 hours of PICU admission | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objective: 1. To study the correlation between TCD derived CBFV phenotypes with A. Hemodynamic parameters (HR, MAP, Lactates, perfusion index). B. Electro cardiometry derived cardiac output indices. C. NIRS derived regional cerebral oxygenation parameters. 2. To study the association between TCD derived CBFV phenotypes with the clinical outcomes A. Duration of inotrope requirement B. Duration of mechanical ventilation C. Duration of PICU/hospital stay. D. Morbidity – sepsis-associated encephalopathy. E. Mortality. Timepoint: At the time of discharge from hospital | — |
Countries
India
Contacts
Public ContactAMIT KUMAR
St Johns medical college bangalore
Outcome results
None listed