A clinical trial to compare early restrictive and liberal fluid management for resistant hypotension in septic shock patients.

Restrictive vs Liberal fluid management in sepsis induced hypotension - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070935

Enrollment

364

Registered

2024-07-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R99-R99- Ill-defined and unknown cause of mortality

Interventions

Intervention1: Restrictive fluid therapy: Group A consist of patients with sepsis induced hypotension presented to ICU within 6 hours of hospital admission and MAP less than 65 mmHg first Vasopressor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patient from 18-65 years of age with sepsis induced hypotension confirmed through SIRS diagnostic criteria with MAP less than 65 mmHg

Exclusion criteria

Exclusion criteria: Previous reception of greater 3000ml of IV fluid Elapse of greater than 6 hour on admission to hospital End stage renal failure Elevated jugular venous pressure Gastrointestinal bleeding in absence of fever congestive heart failure

Design outcomes

Primary

Measure	Time frame
Death from any cause before discharge home or by day 90Timepoint: 90 days	—

Secondary

Measure	Time frame
day free from renal replacement therapyTimepoint: Day 90;Day out of CCUTimepoint: By day 90;Days free from vasopressor useTimepoint: Day 90;Days free from ventilator useTimepoint: 90 days	—

Countries

India

Contacts

Public ContactDr Anamika Tiwari

Pt JNM Medical College Raipur CG

jayalalwani2020@gmail.com9300224989

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026