Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
Conditions
Interventions
Intervention1: Nebulized Polymyxin E: Polymyxin E 5.5 mg/kg/day for 3 consecutive days in the nebulized form .The drugs will be given twice daily for 3 consecutive days
with the help of vibrating mesh
Sponsors
Uttarpradesh University of medical sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients who are expected to be on mechanical ventilation for at least 72 hours.
Exclusion criteria
Exclusion criteria: 1. Patients who are already on mechanical ventilation for more than 96 hours. 2.Patients who are already diagnosed with or a suspected case of pneumonia 3.Patient with chronic kidney disease 4. Positive pregnancy test at the time of inclusion 5. Patient scheduled for extubation within the next 24 hours 6. Patient known to be allergic to aminoglycosides or polypeptide antibiotics at the time of inclusion. 7. Patients who are already on systemic aminoglycoside or polypeptides antibiotics 8.Patients who are tracheostomized.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the first episode of VAP in between the two groups from randomization to Day 28 on the basis of Clinical Pulmonary Infection Score(CPIS),Timepoint: 28 Days | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the median number of days from randomization to first successful spontaneous breathing trial.Timepoint: 28 Days;Adverse reaction in between the two groups due to nebulization.Timepoint: 28 Days;To compare the median length of stay in days (ICU and Hospital).Timepoint: 28 Days;To compare the median number of days on mechanical ventilation from randomization to Day 28.Timepoint: 28 Days | — |
Countries
India
Contacts
Public ContactHarish Kumar
Uttarpradesh university of medical sciences
Outcome results
None listed